|

The use of nanoparticles for targeted drug delivery

Authors: Korolev V.S.
Published in issue: #4(45)/2020
DOI: 10.18698/2541-8009-2020-4-600


Category: Medical sciences | Chapter: Medical equipment and devices

Keywords: nanotechnology, medicine, liposomes, nanoparticles, drug delivery, drugs, vesicles, ferromagnetic particles, phospholipids
Published: 08.05.2020

The paper is devoted to the methods of drug delivery in the field of nanotechnology using liposomes and ferromagnetic nanoparticles. Medical nanoparticles are the subject of one of the most famous and promising sections of nanotechnology in our time. The small size of such particles opens up new possibilities for interaction with the human body. Such application of nanotechnology is targeted drug delivery: the active substance is “transported” in special nanoparticles that deliver it to the right place and release it. Various aspects of these technologies are considered: the production of nanoparticles, their practical use, safety of use, particle structure and potential for further development for liposomes and ferromagnetic particles.


References

[1] Adamova A.A., Shvedova A.G., Firsov A.A. Analysis of the application of electrophysical methods and means in psychiatry and neurology. Tekhnologii inzhenernykh i informatsionnykh system [Technologies of Engineering and Information Systems], 2019, no. 3, pp. 53–62 (in Russ.).

[2] Kreuter J. Nanoparticles and microparticles for drug and vaccine delivery. J. Anat., 1996, vol. 189, no. 3, pp. 503–505.

[3] Çağdaş M., Sezer A.D. Bucak S. Liposomes as potential drug carrier systems for drug delivery, application of nanotechnology in drug delivery. IntechOpen, 2014. DOI: https://doi.org/10.5772/58459

[4] Strekalova O.S. Fosfolipidnye nanochastitsy: poluchenie, kharakteristika, ispol’zovanie dlya transporta lekarstv v organizme. Diss. kand. biol. nauk [Phospholipid nanoparticles: obtaining, characteristics, application for medicine transport in organism. Kand. biol. sci. diss.]. Moscow, IBMKh RAMN Publ., 2010 (in Russ.).

[5] Torchilin V. Multifunctional nanocarriers. Adv. Drug Deliv. Rev., 2006, vol. 58, no. 14, pp. 1532–1555. DOI: https://doi.org/10.1016/j.addr.2006.09.009

[6] Roduner E. Razmernye effekty v nanomaterialakh [Size effects in nanomaterials]. Moscow, Tekhnosfera Publ., 2010 (in Russ.).

[7] Estelrich J., Escribano E., Queralt J., et al. Iron oxide nanoparticles for magnetically guided and magnetically responsive drug delivery. Int. J. Mol. Sci., 2015, vol. 16, no. 4, pp. 8070–8101. DOI: https://doi.org/10.3390/ijms16048070

[8] Zadoshenko E.G., Burlakova V.E. Study of ferromagnetic nanoparticles effect on tribotechnical lubricating characteristics. Vestnik DGTU [Vestnik of Don State Technical University], 2015, no. 1(80), pp. 85–92. DOI: https://doi.org/10.12737/10391 (in Russ.).

[9] Jain K., Mehra N.K., Jain N.K. Nanotechnology in drug delivery: safety and toxicity issues. Curr. Pharm. Des., 2015, vol. 21, no. 29, pp. 4252–4261.